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目的:探讨取宫内节育器(IUD)后继发不孕妇女血清中抗精子抗体(AsAb)、抗子宫内膜抗体(EMAb)、抗卵巢抗体(AoAb)和抗心磷脂抗体(ACA)的发生率及其作用,为临床病因分析和治疗提供依据。方法:采用酶联免疫吸附法(ELISA)对96例取IUD后继发不孕妇女、270例原发不孕妇女和50例正常生育未置IUD妇女(对照组)血清AsAb、EMAb、AoAb和ACA进行检测,并对检测结果进行统计分析。结果:取IUD后继发不孕妇女血清AsAb阳性32例(33.3%),EMAb阳性26例(27.1%),AoAb阳性21例(21.9%),ACA阳性25例(26.0%)其阳性率均显著高于对照组(P<0.01),同时AsAb和EMAb阳性率分别显著高于原发不孕组(P<0.01)。结论:取IUD后继发不孕妇女血清中AsAb、EMAb、AoAb和ACA阳性率显著升高,这可能是取IUD后继发不孕的一个重要原因。对取IUD后不孕妇女进行血清AsAb、EMAb、AoAb和ACA的检测具有一定意义。
Objective: To investigate the effects of anti-sperm antibody (AsAb), anti-endometrial antibody (EMAb), anti-ovarian antibody (AoAb) and anti-cardiolipin antibody (ACA) in women with secondary infertility after intrauterine device (IUD) Rate and its role, provide the basis for clinical etiological analysis and treatment. Methods: Serum AsAb, EMAb, AoAb and ACA were detected by enzyme-linked immunosorbent assay (ELISA) in 96 cases of IUD infertile women, 270 cases of primary infertile women and 50 cases of normal pregnant women without IUD (control group) For testing, and test results for statistical analysis. Results: The positive rate of serum AsAb was 32 (33.3%), 26 (27.1%) were EMAb positive, 21 (21.9%) were AoAb positive and 25 (26.0%) were ACA positive after IUD. (P <0.01), while the positive rates of AsAb and EMAb were significantly higher than those of the primary infertility group (P <0.01). Conclusion: The positive rates of AsAb, EMAb, AoAb and ACA in serum of secondary infertile women after IUD retrieval are significantly higher, which may be one of the important causes of secondary infertility after IUD. Detection of serum AsAb, EMAb, AoAb and ACA in infertile women who have taken IUD has some significance.