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已有许多研究证实格林－巴利综合征（ＧＢＳ）与前驱空肠弯曲菌（Ｃｊ）感染有密切关系。但是，Ｃｊ诱发ＧＢＳ的病理机制仍不明确。作者试图探讨Ｃｊ菌体成份与ＧＢＳ发病的关系。以一株自ＧＢＳ患者分离得到的Ｃｊ之脂多糖（ＬＰＳ）为抗原，用酶联免疫吸附试验（ＥＬＩＳＡ）方法，检测了ＧＢＳ患者组（观察组）和健康成人组（对照组）的血清抗空肠弯曲菌脂多糖抗体。结果ＧＢＳ组血清呈阳性反应者为２０／３７（５４％）、对照组血清呈阳性反应的为１／３６（３％），差别具有统计学意义（Ｐ＜０．００１，ｘ２）。提示多数ＧＢＳ患者血清中存在着不同于健康人群的ＣｊＬＰＳ特异抗体．
Many studies have confirmed that Guillain-Barre syndrome (GBS) is closely related to the infection of C. jejuni. However, the pathological mechanism of Cj-induced GBS remains unclear. The author attempts to investigate the relationship between Cj and GBS pathogenesis. A Cb lipopolysaccharide (LPS) isolated from patients with GBS was used as antigen. Serum anti-GBS patients (control group) and GBS patients (control group) were tested by enzyme linked immunosorbent assay (ELISA) Campylobacter jejuni lipopolysaccharide antibody. Results Serum of GBS group was 20/37 (54%) positive for serum and 1/36 (3%) for serum of control group, the difference was statistically significant (P <0.001, x2). It is suggested that the majority of GBS patients have different CjLPS specific antibodies in healthy people.