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失眠作为一种常见的疾病,严重影响人们的生活质量和工作。1995年Gallup调查统计在美国有49％的成年人患有不同程度的睡眠障碍,其中12％的人有经常性失眠。妇女、60岁以上老人及有抑郁病史者更易发生。当今中国,社会竞争日益激烈,失眠病人也必然越来越多。 目前临床使用的治疗失眠的苯二氮(艹卓)类催眠药虽然可以使病人入睡,但改变失眠病人的自然睡眠、宿醉现象较为严重,难以满足病人需要。因此开发安全、有效、副作用少的药物为临床上所急需。
Insomnia as a common disease, seriously affecting people’s quality of life and work. Gallup 1995 survey statistics in the United States, 49% of adults suffer from varying degrees of sleep disorders, of which 12% of people have recurrent insomnia. Women, older people over 60 and people with depressive history are more likely to develop. In today’s China, the social competition is getting fiercer and the number of insomnia patients is also bound to be more and more. At present, the clinically used benzodiazepine hypnotic drugs for treatment of insomnia can make the patient fall asleep, but change the natural sleep of the insomnia patient, and the hangover phenomenon is more serious, which is difficult to meet the needs of the patient. Therefore, the development of safe, effective, less side effects of drugs is clinically urgent.