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目的:探讨硬膜外人参皂苷药囊电极对兔蛛网膜下腔出血脑血流动力学的影响及意义。方法:健康新西兰大白兔32只,随机分成人参皂苷药囊电极治疗组和尼莫地平对照组,采用兔视交叉注血法制造蛛网膜下腔出血模型,应用64排螺旋CT灌注成像(CT perfusion,CTP)分别测量注血前至14天治疗组和对照组的脑灌注压(CPP),脑血流量(CBF)、脑血容量(CBV)、达峰时间(TPP)及大脑前动脉、大脑中动脉、基底动脉、失状窦、直窦和大脑大静脉直径,并比较两组之间的参数。结果:注血第2～14天治疗组的平均ICP明显低于对照组,而CPP明显高于对照组,治疗组第4～12天的CBF、第2～12天的CBV明显大于对照组,而第4～12天的TPP均小于对照组(P<0.05)。蛛网膜下腔出血第4～14天治疗组上失状窦平均直径均大于对照组,蛛网膜下腔出血第2～14天:治疗组直窦和大脑大静脉直径均大于对照组(P<0.05)。结论:人参皂苷药囊电极与尼莫地平地比较,明显的降低了SAH大白兔ICP和TPP,并增加了引流静脉直径、CPP、CBF和CBV,为蛛网膜下腔出血的治疗提供了一条新的参考途径。
Objective: To investigate the effect and significance of epidural ginsenosides capsule on cerebral hemodynamics in rabbits with subarachnoid hemorrhage. Methods: Thirty-two New Zealand white rabbits were randomly divided into three groups: ginsenoside group and nimodipine group. Subarachnoid hemorrhage model was established by rabbit’s intraocular injection. CT perfusion (CTP) were used to measure the cerebral perfusion pressure (CPP), cerebral blood flow (CBF), cerebral blood volume (CBV), peak time (TPP) and anterior cerebral artery Middle artery, basilar artery, dorsal sinus, straight sinus and cerebral vein, and the parameters between the two groups were compared. Results: On the 2nd to 14th day after injection, the average ICP of the treatment group was significantly lower than that of the control group, while the CPP was significantly higher than that of the control group. The CBF of the 4th to 12th days of the treatment group was significantly greater than that of the control group on the 2nd to 12th days, While the 4th to 12th day TPP were less than the control group (P <0.05). Subarachnoid hemorrhage 4 to 14 days in the treatment group, the average diameter of the droop sinus were larger than the control group, subarachnoid hemorrhage from 2 to 14 days: the treatment group straight sinus and cerebral vein diameter larger than the control group (P < 0.05). Conclusion: Compared with nimodipine, ginsenoside sachet electrodes significantly reduced the ICP and TPP in SAH rabbits and increased the diameter of venous drainage, CPP, CBF and CBV, providing a new treatment for subarachnoid hemorrhage The reference route.