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  5. MET overexpression/amplification predicts the inhibitory effects of anti-MET activity in gastric can

MET overexpression/amplification predicts the inhibitory effects of anti-MET activity in gastric can

来源 :第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会 | 被引量 : 0次 | 上传用户：alexhome
【摘 要】
：
Background: Deregulation of the hepatocyte growth factor(HGF)/MET pathway has been implicated in gastric cancer(GC),representing a potential target in gastric or gastroesophageal junction(G/GEJ)cancer
【作 者】
：
Miaozhen Qiu Rui-Hua Xu 
【机 构】
：
Department of Medical Oncology,Sun Yat-Sen University Cancer Center,State Key Laboratory of Oncology
【出 处】
：
第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会
【发表日期】
：
2016年11期
【关键词】
：
FISH Gastric cancer Immunohistochemistry MET Prognosis 
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　　Background: Deregulation of the hepatocyte growth factor(HGF)/MET pathway has been implicated in gastric cancer(GC),representing a potential target in gastric or gastroesophageal junction(G/GEJ)cancer.However,the anti-tumor effect of anti-MET therapy is still controversial.Methods: We evaluated the expression and amplification of MET in Chinese patients with advanced G/GEJ cancer using different cut-off values and explored the anti-tumor efficacy of a highly selective MET kinase inhibitor,AMG 337,in a panel of 12 GC cell lines.
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