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  5. Mutant Kras-and p16-Regulated NOX4 Activation Overcomes Metabolic Checkpoints in Development of Panc

Mutant Kras-and p16-Regulated NOX4 Activation Overcomes Metabolic Checkpoints in Development of Panc

来源 :第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会 | 被引量 : 0次 | 上传用户：ghostlei
【摘 要】
：
Background: Kras activation and p16 inactivation are required for development of pancreatic ductal adenocarcinoma(PDAC).However,the biochemical mechanisms underlying these double alterations remain un
【作 者】
：
Huai-Qiang Ju Haoqiang Ying Tian Tian Jianhua Ling Jie Fu Min Wu Gang Chen Zhuonan Zhuang Huamin Wang Deepak Nagrath Mien-Chie Hung Ronald A.DePinho Peng Huang Rui-Hua Xu Paul J.Chiao 
【机 构】
：
Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative I
【出 处】
：
第五届广州国际肿瘤学会议暨第一届中国抗癌协会肿瘤靶向治疗专业委员会年会
【发表日期】
：
2016年11期
【关键词】
：
Kras p16 Glycolysis NOX4 NAD+/NADH 
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　　Background: Kras activation and p16 inactivation are required for development of pancreatic ductal adenocarcinoma(PDAC).However,the biochemical mechanisms underlying these double alterations remain unclear.Methods: To study the mechanisms of tumorigenesis in the pancreas,we established an HPNE cell model expressing KrasG12V or KrasG12V/p16shRNA.
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