2. 您的位置
3. 首页
4. 会议论文
5. 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting

3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting

来源 :中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 | 被引量 : 0次 | 上传用户：zeng_hc

【摘 要】

：

OBJECTIVE To investigate 3-0-(Z)-coumaroyloleanolic acid (3-COA), an active ingredient of oleanolic acid in the TAIWANG leaves of E.oldhamii Maxim, that has been shown to have antitumor activity again

【作 者】

：

WANG He GUO Jia-yi MA Lei DENG Sai LIAO Si-yan SUN Ming-na DU Ling-ran PENG Wei WEI Min-yan LIU Bin CHEN Jing-qi ZENG Bo-hang LI Yue-shan YU Xi-yong FENG Ying-hong YI Zhou 

【机 构】

：

The College of Pharmaceutics Science, Guangzhou Medical University, GuangZhou 510436, China;The Seco

【出 处】

：

中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛

【发表日期】

：

2016年11期

【关键词】

：

Cks1b Hsp90 MEK1/2 lung cancer 3-COA chemoresistance 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　OBJECTIVE To investigate 3-0-(Z)-coumaroyloleanolic acid (3-COA), an active ingredient of oleanolic acid in the TAIWANG leaves of E.oldhamii Maxim, that has been shown to have antitumor activity against A549 lung cancer cells, overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways.

其他文献

Microdosing cocktail study on the determination and pharmacokinetics of six hepatic cytochrome probe

OBJECTIVE To describe a highly sensitive LC-ESI MSn method that was developed to simultaneously detect six CYP isoform-specific probes and their metabolites in rat plasma for microdosing cocktail stud

会议

microdosing cocktailhepatic cytochromedrug metabolismprobes and metabolites

The anti-nociceptive effect of bufalin, an active ingredient from toad venom via modulating voltage-

OBJECTIVE Toad venom (Venenum Bufonis) isalways used for analgesia in China from ancient to modern times, but the effective component of it remains unclear.

会议

bufalinsodium channelsformalin testcarrageenan testpatch clamp

Characteristics and pharmacokinetics of tripterygium glycosides nano-carries transdermal delivery sy

The traditional Chinese medicine tripterygium glycosides (TPG) is used clinically to treat some Rheumatism, Eczema, immunosuppression and tumor, with the activities of hypnosis, antipyretic, analgesic

会议

tripterygium glycosidestransdermal drug deliverynano-carriersmicrodialysisnu

Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 syst

OBJECTIVE Cytochrome P450 (CYP) 3A accounts for nearly 30% of total CYP enzymes in human liver and participates in the metabolism of over 50% of clinical drugs.CYP3A also plays an important role in th

会议

compensatory regulationCRISPR-Cas9CYP3Adrug metabolismgene editingrat

Intestine metrnl acts as a local regulator released into gut lumen and maintaining gut antimicrobial

OBJECTIVE Metrnl is a novel secreted protein with limited researches.In this study, we investigated metrnl tissue expression pattern in humans, and explored the possible role of its highest expression

会议

metrnlsecreted proteinhuman expression patternintestineepithelial cellantim

Enoxaparin sensitizes human non-small-cell lung carcinomasto gefitinib by inhibiting DOCK1 expressio

Gefitinib is widely used for the treatment of lung cancer in patients with sensitizing epidermal growth factor receptor mutations, but patients tend to develop resistance after an average of 10 months

会议

enoxaparingefitinibDOCK

Effects of garcinone E on ovarian cancer cells : endoplasmic reticulum stress, apoptosis, migration

OBJECTIVE Garcinone E, a xanthone derivative isolated from mangosteen, has been reported to have cytotoxic capacities.We aim to study the anticancer effects of garcinone E on ovarian cancer cells.

会议

ovarian cancergarcinone EapoptosismetastasisER stress

Gubenyiliu Ⅱ inhibits breast tumor growth and metastasis associated with decreased heparanase expres

OBJECTIVE Gubenyiliu Ⅱ (GY Ⅱ), a traditional Chinese medicine (TCM) formula used in our hospital, has shown beneficial effects in cancer patients.In this study, we investigated the molecular mechanism

会议

Gubenyiliu Ⅱbreast tumorheparanasegrowth factorsERKAKT pathways

Different gap junction-propagated effects on cisplatin transfer result in opposite responses to cisp

OBJECTIVE Previous work has shown that gap junction intercellular communication (GJIC) enhances cisplatin (Pt) toxicity in testicular tumor cells but decreases it in non-tumor testicular cells.In this

会议

tumor cellsnon-tumor cellsGJICcisplatincopper transporter 1multidrug resist

A polymorphism in GAS5 promoter impacts efficacy of cytarabine-based chemotherapy in Chinese AML pat

OBJECTIVE SNPs in IncRNAs may alter the expression or secondary structure of IncRNAs and then impact their functions.Whether IncRNA SNPs affect the prognosis of acute myeloid leukemia (AML) remains un

会议

growth arrest specific 5single nucleotide polymorphismacute myeloid leukemial