Cell softness prevents cytolytic T cell killing of tumor-repopulating cells

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户:kyy06
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Objective Despite the unprecedented success of the clinical application of programmed cell death receptor 1(PD-1)blockade antibodies and CAR-T therapy,treated cancer patients,who initially respond and show extraordinary treatment outcomes,still relapse.
其他文献
Objective T follicular helper(Tfh)cells formed in germinal center are a distinct subpopulation of CD4+T cell,coexpressing high levels of CXCR5,ICOS,PD-1,Bcl-6 and CXCL13 as their characteristic marker
Objective The leukocyte integrin LFA-1(CD11a/CD18),which belongs to the β 2 integrin family,is an adhesion factor and plays an important role in the leukocyte trafficking and tumor immune cells.It is
目的 三级淋巴样结构(Tertiary lymphoid structures,TLS),又称三级淋巴样器官(Tertiary lymphoid organs,TLO)或异位淋巴样结构(Ectopic lymphoid structures,ELS),后天在慢性炎症作用下形成于外周非淋巴器官(肝脏、肺、肾脏),可见于多种疾病,包括:慢性感染、自身免疫性疾病(Autoimmune diseases,
目的 脂肪组织可以通过旁分泌和内分泌的途径对乳腺肿瘤的发生和发展起到易化作用,而脂肪组织来源干细胞(adipose tissue-derived stem cell,ASC)很可能是促进乳腺肿瘤发生和发展的主要细胞类型。
目的 阐明IL-32 调控MΦ s 极化进而诱导MM 细胞耐药的作用,探讨IL-32 发挥作用的具体分子机制。方法 用qRT-PCR、Western blot(WB)、ELISA 检测原代MM 细胞、MM 细胞株、MΦ s、骨髓基质细胞(BMSCs),MM 患者外周血血清以及骨髓上清中IL-32 的表达和分泌情况。
Objective Multiple myeloma(MM)is a B-cell malignancy characterized by the proliferation of plasma cells in the bone marrow(BM).Aberrant glycosylation,as a common post-translational modification in mal
Objective Exploiting gut mucosal immunity to design new antitumor vaccination strategy remains unexplored.Tumor cell-derived microparticles(T-MP)are natural biomaterials that are capable of delivering
目的 从细胞代谢与细胞骨架二者相结合的角度进行分析,以乳腺癌为研究对象,对乳酸和NMHCIIA 进行检测,并通过抑制AKT 影响乳酸代谢,进而观察降低乳酸含量对肿瘤生物学行为的影响,来综合分析乳酸含量变化调控肌球蛋白重链而引起乳腺癌细胞的侵袭过程。