Objective T follicular helper(Tfh)cells formed in germinal center are a distinct subpopulation of CD4+T cell,coexpressing high levels of CXCR5,ICOS,PD-1,Bcl-6 and CXCL13 as their characteristic marker
Objective The leukocyte integrin LFA-1(CD11a/CD18),which belongs to the β 2 integrin family,is an adhesion factor and plays an important role in the leukocyte trafficking and tumor immune cells.It is
Objective Multiple myeloma(MM)is a B-cell malignancy characterized by the proliferation of plasma cells in the bone marrow(BM).Aberrant glycosylation,as a common post-translational modification in mal
Objective Exploiting gut mucosal immunity to design new antitumor vaccination strategy remains unexplored.Tumor cell-derived microparticles(T-MP)are natural biomaterials that are capable of delivering