MDR1,GSTP1基因遗传变异与上皮性卵巢癌患者临床预后的关系

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：nvli2010

【摘要】

：

目的:卵巢恶性肿瘤(上皮性卵巢癌,EOC)是女性生殖系统常见的三大恶性肿瘤之一,患者5年生存率约30％.晚期EOC患者的治疗包括手术和术后以铂类为基础的辅助化疗,但患者对铂类的耐药严重影响了化疗疗效,成为治疗EOC的一大障碍.铂类耐药可能受累于多种机制,个体遗传因素所导致的对药物的反应差异在治疗中起着重要作用.本研究拟探讨MDR1和GSTP1基因遗传变异与上皮性卵巢癌患者铂类耐药及临床预后的关系,

【作者】

：

李琰赵一诺康山王娜周荣秒

【机构】

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河北医科大学第四医院分子生物学研究室河北医科大学第四医院妇科

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

MDR1 GSTP1 单核苷酸多态性(SNP) 卵巢上皮性癌铂类化疗临床预后

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MDR1,GSTP1基因遗传变异与上皮性卵巢癌患者临床预后的关系

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