Synthesis and Biological Activity of Chiral Gossypolic Acids as Entry Inhibitors against H5N1

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户:yt58458665
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  In the present anti-H5N1 experiments,a very interesting phenomenon attracted us,(+)-gossypol showed comparable activity with(-)-gossypol.This prompted us to carry out further comprehensive comparisons of the anti-H5N1 activity of chiral gossypol derivatives and its analogs.To better understand the anti-H5N1activity of (+)/(-)-Gossypolic acid,(+)/(-)-Gossypolic acid were synthesized(see Scheme 1),and their anti-H5Nl activity was also tested.
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