EAE模型病理学特征多样性的机制研究

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：yjddstevens

【摘要】

：

背景和目的:多发性硬化的临床表现、影像学改变和病理表现个体差异较大,但机制不明确.利用实验性自身免疫性脑脊髓炎模型研究已经发现不同的磷脂抗原特异性淋巴细胞免可诱导大鼠产生神经组织抗原特异性病灶分布及不同程度的神经组织炎性细胞浸润.病毒感染可能是影响MS发病的重要因素,推测分子模拟可能参与发病.基于以上研究,拟采用不同磷脂肽段免疫Lewis大鼠,探索临床体征和病理学特点是否存在差异;探索病毒模拟肽段

【作者】

：

郑梅梅王拥军张星虎

【机构】

：

山东省千佛山医院首都医科大学附属北京天坛医院

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

髓鞘碱性蛋白髓鞘少突胶质细胞糖蛋白实验性自身免疫性脑脊髓炎病理学特征分子模拟

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EAE模型病理学特征多样性的机制研究

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