柯萨奇病毒B3诱导细胞产生的自噬及其分子机制的研究

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：zcv_2323

【摘要】

：

研究背景:柯萨奇病毒B3 (Coxsackievirus B3,CVB3)是一类无囊膜包被的单正链小RNA病毒,是引起病毒性心肌炎的主要病原体之一.研究表明CVB3感染可以引起心肌细胞自噬(autophagy),但是CVB3诱导自噬的具体分子机制和病毒性心肌炎的关系还未明确.目的:本研究主要探讨了CVB3与自噬之间的关系以及CVB3诱导自噬的相关分子机制.

【作者】

：

陈子健唐圣洁熊思东董春升

【机构】

：

苏州大学生物医学研究院

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

自噬 CVB3 病毒性心肌炎 GFP-LC3

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

The potential role of microRNA-7 in the development of immune cells

Background & Aims: microRNA-7 (miR-7), a member of miRNA family, which was demonstrated played important roles in various tumor diseases.Accumulating evidences suggested that distinct miRNA molecules

会议

miR-7knock downdevelopmentimmune cells

COX-1 derived thromboxane A2 plays an essential role in early B cell development via regulation of J

Cyclooxygenases (COXs) and their prostanoid products play important roles in a diverse range of physiological processes, including in the immune system.Here, we provide evidence that COX-1 is an essen

会议

Detection of serological anti-F antibodies in HCV persistence and resolved patients

Background: To investigate the plasma serological differences of anti-F antibodies between chronic and recovered infections.Methods: Subtype 1b of F or C protein was used as coated antigen to assess t

会议

Subtype 1b Hepatitis C virusSerological detectionF proteinCore protein (C pro

The SDF-1/CXCR4 axis is required for early recruitment of activated CD8+ T cells in visceral adipose

Background: Obesity-induced visceral adipose tissue (VAT) inflammation is a key factor leading to insulin resistance and type 2 diabetes.The early recruitment of CD8+ T cells into VAT has been shown t

会议

CD8+T cellSDF-1/CXCR4adipose tissueobesityinflammation

Effects of high glucose on the expression of OPG and RANKL in rat aortic vascular smooth muscle cell

Background: Diabetic arterial calcification has been indicated as a strong predictor of cardiovascular mortality.Vascular smooth muscle cells (VSMCs) differentiate into osteoblast-like cells plays a p

会议

BML-111 protected carbon tetrachloride-induced hepatic fibrosis in rats and the possible mechanisms

Objective: LXs are a class of newly found arachidonic acid metabolites, possess potent anti-inflammatory and proresolution effects.We had previously confirmed the LXs agonists BML-111 had possessed th

会议

Lipoxinshepatic fibrosisHepatic stellate cellinflammation

HLAⅠ类抗原呈递通路基因ERAP1和ERAP2基因多态性与丙型肝炎病毒慢性感染的相关性研究

背景:在机体病毒感染后的清除中,宿主免疫应答发挥了重要的作用.与抗原递呈密切相关的HLA系统,在对病毒的有效应答中起着关键作用.内质网氨肽酶1和2 (endoplasmic reticulum aminopeptidase 1 and 2,ERAP1 and ERAP2)是抗原递呈中的重要分子,已有研究报道,ERAP1基因的多态性与自身免疫性疾病、慢性感染性疾病的发生发展有着密切的关联性.目的ER

会议

ERAP基因HCV慢性感染单核苷酸多态性

The lipoxin receptor agonist BML-111 protects against LPS/D-GalN-induced acute liver injury in rats

Objective: Lipoxins (LXs), a class of arachidonic acid metabolites, display unique anti-inflammatory and pro-resolving actions in a variety of inflammatory diseases.The present study was undertaken to

会议

Lipoxinsliver injuryantioxdationinflammation

Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct

Cholesterol 25-hydroxylase (CH25H) as an interferon-stimulated gene (ISG) has recently been shown to exert broad antiviral activity through the production of 25-hydroxycholesterol (25HC), which is bel

会议

Coronavirus papain-like proteases induce incomplete autophagy through interacting with Beclin 1 to n

Autophagy plays important roles in modulating viral replication and antiviral immune response.Coronavirus infection is associated with the autophagic process, however, little is known about the mechan

会议

CoronavirusPapain-like proteaseAutophagyAntiviral immunityBeclin 1STING

柯萨奇病毒B3诱导细胞产生的自噬及其分子机制的研究

与本文相关的学术论文