Study on nano hydroxyapatite / Polyamide 66 / chitosan / erythromycin composite bone repair material

来源 :2016’中国溶胶-凝胶学术研讨会暨国际论坛 | 被引量 : 0次 | 上传用户:CHENYF20000
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  Nano hydroxyapatite (n-HA), polyamide 66 (PA66) and chitosan (Cs) are often use as a kind of biomaterials due to their excellent properties, especially in bone repair materials.And Erythromycin (EM) is a broad spectrum antibiotic that can be used to reduce the postoperative inflammatory reaction.Firstly, we prepared n-HA/PA66/CS (4∶4.5∶1.5) composite materials (CM) powder, and loaded EM (CM∶ EM=100∶3 w/w) via solvent casting method at 60 ℃.And then, the materials finally formed in mold at room temperature.Finally, the composite materials powder would be press in mold to form a 13mm pill, which used as a kind of bone repair materials.In order to evaluate the properties of materials, the mechanical property, Tg, XRD, FTIR, drug release properties would be taken.The results of mechanical properties show that compress strength of the materials is 1.47MPa, fragility of the materials is 0.40.And the FTIR and XRD show that the addition of EM does not affect the chemical composition and the crystal structure of the composites materials.Finally, the result of drug release properties of composite materials shows that highest releasing concentration of EM occur in 24 h, and the drug release effect can last up to seven days.
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