【摘 要】
：
sSema 4D is a 120 kDa tran membrane protein that belongs to the semaphorin family of axonal guidance, also is the first semaphorin described to have immune functions and play important roles in T cell
【机 构】
：
Key Laboratory of Advanced Technology of Materials, Chinese Education Ministry, School of Materials
【出 处】
：
第十一届全国表面工程大会暨第八届全国青年表面工程学术会议
论文部分内容阅读
sSema 4D is a 120 kDa tran membrane protein that belongs to the semaphorin family of axonal guidance, also is the first semaphorin described to have immune functions and play important roles in T cells priming, cell to cell adhesion and antibody productions. Plexin B1 is known to be the receptor for sSema 4D in non-lyphoid tissues, CD72 functions as its receptor in lymphoid tissue. sSema 4D elicits an migration-promoting effects through stimulating plexin B1 and an immun modulation effect through CD72. In our present works, sSema 4D combined with heparin was introduced onto cation surfaces. According to biocompatibility evaluation results, the sSema 4D/heparin modified surfaces displayed less platelet adhesion and activation, and prolonged APTT, PT and TT values. Furthermore, the adhesion density and proliferation activity of ECs were improved for sSema 4D/heparin modified samples. Chemotactic and haptotaxis assays indicated a highly directed migration for ECs on modified surfaces. The immune tests illustrated that the sSema 4D/heparin had a positive immun modulation effect on macrophages , and promoted macrophages polarizing into M2 phenotypes. All results suggested that the sSema 4D/heparin complexes maybe used as a potential candidate to promote tissue healing and accelerate endothelialization with low side effects and positive immun modulatory effect.
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