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目的研究利用地塞米松诱导大鼠胰岛素抵抗,建立大鼠高血糖模型。方法试验设空白对照组、模型对照组、罗格列酮治疗组。空白对照组给予普通鼠维持饲料,模型组及罗格列酮组给予高热量饲料,罗格列酮组给予2 mg/kg BW罗格列酮灌胃,2周后,模型组及罗格列酮组在此基础上每天再给予地塞米松0.8 mg/kg BW腹腔注射连续14 d后,测空腹血糖、糖耐量及胰岛素。结果 0.5 h时模型对照组血糖值高于空白对照组(P<0.05);模型对照组血糖曲线面积大于空白对照组模型(P<0.05);模型对照组胰岛素与空白对照组比较,差异无统计学意义(P>0.05)。结论地塞米松诱导胰岛素抵抗大鼠模型成立。
Objective To study the use of dexamethasone-induced insulin resistance in rats to establish a rat model of hyperglycemia. Methods The experiment set blank control group, model control group, rosiglitazone treatment group. The blank control group was given normal rats to maintain feed, the model group and the rosiglitazone group were given high-calorie feed, rosiglitazone group was given 2 mg / kg BW rosiglitazone gavage, 2 weeks later, model group and rosiglitazone On the basis of this, the ketamine group was given daily dexamethasone 0.8 mg / kg BW for 14 consecutive days and the fasting blood glucose, glucose tolerance and insulin were measured. Results The blood glucose of the model control group was significantly higher than that of the blank control group at 0.5 hour (P <0.05), and the blood glucose curve area of the model control group was larger than that of the blank control group (P <0.05). There was no significant difference between the model control group and the blank control group Significance (P> 0.05). Conclusion Dexamethasone-induced insulin resistance rat model was established.