台湾海峡放线菌中安莎类抗生素的资源挖掘

来源 :第一届中-欧放线菌生物学研讨会 | 被引量 : 0次 | 上传用户：lszll2008

【摘要】

：

近年来,抗生素的重复分离和细菌抗药性等成为研发新抗生素的瓶颈,迫使研究者采用新方法来挖掘新的活性抗生素资源.我们采用从基因到产物的新挖掘模式,即根据已知活性抗生素的

【作者】

：

凡琴郑忠辉黄耀坚吴莹莹

【机构】

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厦门大学生命科学学院,细胞应激生物学国家重点实验室,福建厦门361005

【出处】

：

第一届中-欧放线菌生物学研讨会

【发表日期】

：

2013年4期

【关键词】

：

安莎类抗生素简并引物 PCR筛选 Southern杂交

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近年来,抗生素的重复分离和细菌抗药性等成为研发新抗生素的瓶颈,迫使研究者采用新方法来挖掘新的活性抗生素资源.我们采用从基因到产物的新挖掘模式,即根据已知活性抗生素的生物合成途径中关键酶的保守序列,设计简并引物,通过PCR筛选潜在的抗生素产生菌,并经过测序验证和比对,研究这些菌株的关键酶基因序列间的同源性和多样性.

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台湾海峡放线菌中安莎类抗生素的资源挖掘

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