Role of sgcR in Negative Regulation of Enediyne Antibiotic C-1027 Production in Streptomyces globisp

来源 :第一届中-欧放线菌生物学研讨会 | 被引量 : 0次 | 上传用户:jin1067061730
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
C-1027, also called lidamycin, is an extremely potent antitumor antibiotic isolated from Streptomyces globisporus C-1027.C-1027 is currently undergoing phase Ⅱ clinical trials in China.
其他文献
  为探索肺炎克雷伯氏菌微胶囊疫苗的免疫效果,本研究通过喷雾-界面配位改良法制备了肺炎克雷伯氏菌微胶囊疫苗,取清洁级昆明小鼠(雌性)200只,随机分为5组:Ⅰ为松花粉多糖胶
  为研究泰山松花粉多糖(TPPPS)对禽波氏杆菌外膜蛋白A(ompA)基因工程亚单位疫苗在小鼠体内免疫反应的影响,将禽波氏杆菌ompA基因克隆到pUC19质粒测序后连接到pET32a+表达
  哈氏噬纤维菌(Cytophag hutchinsonii)是存在于土壤中的一类丰富的好氧细菌,具有极强的结晶纤维素降解能力,但其降解机制目前尚不清楚.该菌全基因组序列于2007年测序完成
会议
  本研究以酿酒酵母ura3营养缺陷型α型单倍体菌株JM为出发菌株,对其XV染色体进行精简操作,即缺失掉其中大片段非必需基因,为构建具有简约基因组的酿酒酵母细胞奠定基础。本研
Xantholipin isolated from Streptomyces flavogriseus is a hexacyclic aromatic polyketide with potent antitumor activity.Previous studies have cloned its biosynth
会议
  结构新颖的的细胞毒类药物-埃博霉素(Epothilones)的问世引起了极大关注。埃博霉素是由纤维堆囊菌(Sorangium cellulosum)分泌的以16元大环内酯为母核,噻唑环配基为侧链的
Lantibiotics are ribosomally synthesized, post-translationally modified antimicrobial peptides produced by gram-positive bacteria.Due to their novel and specifi
会议
Actinomycetes are still the most prolific producers of pharmacologically important compounds, accounting for about 70% of the naturally derived antibiotics that
会议
羊毛硫细菌素是一类由革兰氏阳性菌核糖体合成并经翻译后修饰的小肽,因其独特抗菌机制不易引起抗药性或作为重要生理调节因子而倍受关注.Bovicin HJ50是本室自牛奶中分离的牛
会议
The taxonomic status of Amycolatopsis underwent a long-term and complicated revision history.It was once considered as a streptomycete, then transferred to Noca