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5. 氧化白藜芦醇通过抗血管和淋巴管新生作用抑制小鼠H22肝癌生长及淋巴结转移

氧化白藜芦醇通过抗血管和淋巴管新生作用抑制小鼠H22肝癌生长及淋巴结转移

来源 :中国药理学会第十三届全国化疗药理学术研讨会 | 被引量 : 0次 | 上传用户：bodeying123

【摘 要】

：

目的：通过建立小鼠H22肝癌淋巴结转移模型,考察氧化白藜芦醇(Oxyresveratrol,Oxyres)体内抗肿瘤生长及淋巴结转移活性。方法：MTT法及Transwell法考察Oxyres对肝癌细胞株QGY-7701,SMMC-7721体外增殖和迁移的作用。小鼠爪垫皮下接种H22肝癌细胞,建立小鼠肿瘤转移模型。荷瘤小鼠随机分为：模型对照组(Model),Oxyres20,40,60 mg/kg组

【作 者】

：

任为 周黎明 

【机 构】

：

四川大学华西基础医学与法医学院药理教研室,成都 610041

【出 处】

：

中国药理学会第十三届全国化疗药理学术研讨会

【发表日期】

：

2016年4期

【关键词】

：

氧化白藜芦醇 白藜芦醇 H22 淋巴结转移 

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　　目的：通过建立小鼠H22肝癌淋巴结转移模型,考察氧化白藜芦醇(Oxyresveratrol,Oxyres)体内抗肿瘤生长及淋巴结转移活性。方法：MTT法及Transwell法考察Oxyres对肝癌细胞株QGY-7701,SMMC-7721体外增殖和迁移的作用。小鼠爪垫皮下接种H22肝癌细胞,建立小鼠肿瘤转移模型。荷瘤小鼠随机分为：模型对照组(Model),Oxyres20,40,60 mg/kg组,白藜芦醇(Res)40 mg/kg组,阿霉素5mg/kg组(ADM),同时设正常对照组(Normal),共7组(n=10)。

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