【摘 要】
：
研究背景:牙龈间充质干细胞(GMSCs)被认为可以用来治疗多种自身免疫性疾病,包括免疫性结肠炎,自身免疫性关节炎等.然而还尚无GMSCs是能够治疗急性移植物抗宿主病的研究报道.研究目的:我们通过研究GMSCs在急性移植物抗宿主病模型中的作用,鉴别GMSCs保护aGVHD的保护作用,并探究其保护机制与原理.方法:我们运用GMSCs治疗两种不同的小鼠急性移植物抗宿主病模型,通过流式检测监测供者,受者来
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
研究背景:牙龈间充质干细胞(GMSCs)被认为可以用来治疗多种自身免疫性疾病,包括免疫性结肠炎,自身免疫性关节炎等.然而还尚无GMSCs是能够治疗急性移植物抗宿主病的研究报道.研究目的:我们通过研究GMSCs在急性移植物抗宿主病模型中的作用,鉴别GMSCs保护aGVHD的保护作用,并探究其保护机制与原理.方法:我们运用GMSCs治疗两种不同的小鼠急性移植物抗宿主病模型,通过流式检测监测供者,受者来源的T,B细胞数量变化情况以及细胞因子的变化情况.体外实验中,将GMSCs与na(i)ve T细胞在IL-2和TGF-β的环境下共培养,检测其Foxp3以及CD39的表达.在一些实验中抗CD39抗体被用来拮抗CD39+T细胞,观测拮抗CD39+T细胞后,GMSCs治疗移植物抗宿主病模型的生存率.最后,我们还监测了腺苷受体A1,A2A,A2B,A3在GMSCs保护aGVHD中的作用.
其他文献
To study the influence of neuron contact on the differentiation o f mesenchymal stem cells (MSCs) into neuron-like cells.MSCs and neurons of rat were co-cultured with or without direct cell-cell conta
The aim of the study was to assess whether gap junctions would control the expression of LC3 in TBI.Adult male SD rats were subjected to TBI.gap junction protein levels and LC3-II levels were quantifi
Aquaporin 4 (AQP4) plays an important role in maintaining brain water homeostasis when it cluster at the perivascular astrocyte endfeet.In the brain of intracerebral hemorrhage (ICH), little is known
Intraneuronal accumulation of beta-amyloid protein (Aβ) is one of the earliest pathological events in Alzheimers disease (AD).Recent studies demonstrate that a7 nicotinic acetylcholine receptor (α7nAC
To examine the alteration of aquaporin-4 expression and investigate the occurrence of aquaporin-4 internalization in rat brain edema induced by ischemia-reperfusion injury.The rat brain ischemia-reper
To examine the effect of the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) on the expression of aquaporin-4 in the rat brain with meningitis.Group B hemolytic Streptococcus was inje
Aqauporin 9 (AQP9) is one member of aquaglyceroporins,another important aquaporin except AQP4 in brain.Here, to clarify roles of AQP9 and its regulation after ischemia, we examined the expression patt
Memory deficit is one of the prominent symptoms of Alzheimers disease (AD).Memory is associated with monocarboxylate transporter (MCT1, MCT2, and MCT4) mediated neuron-glia metabolic coupling in the b
Background:Hepatitis C virus (HCV) persistence is associated with chronic necroinflammatory liver disease with dysfunctional antiviral T cells, induction of immune inhibitory pathways and the emergenc
Background and Aims: Increasing evidence suggests that commensal probiotic species regulate a number of host processes, including nutrition and immune responses that are relevant for both health and d