Recently,the core/shell hybrid construction has attracted more attention since these nanostructures can boost structural stability and introduce new physics properties.Particularly,noble metal shell layers such as Ag and Au are focused extensively.1-5 So,it is important to control the drug release and detect the distribution of drug molecules before and after release.In this work,liposome@AgAu nanocomposites is presented for drug delivery,which can not only control the release of drug but also target drug molecules by surface enhanced Raman scattering(SERS)and fluorescence signal during the release process.