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5. Identify old drugs as potent and selective microbiome β-glucuronidase inhibitors

Identify old drugs as potent and selective microbiome β-glucuronidase inhibitors

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：zjie16

【摘 要】

：

By using β-glucuronidase enzyme,microbiota in gastrointestinal(GI)scavenge sugar from glucuronidated compounds as a source of carbon,resulting in activation of drugs from its non-toxic form to toxic c

【作 者】

：

Ren Kong Lianhua Piao Xiaoshuang Xu 

【机 构】

：

Institute of Bioinformatics and Medical Engineering,School of Electrical and Information Engineering

【出 处】

：

中国化学会第十届全国化学生物学学术会议

【发表日期】

：

2017年10期

【关键词】

：

β-glucuronidase inhibitors old drug new use virtual screening 

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　　By using β-glucuronidase enzyme,microbiota in gastrointestinal(GI)scavenge sugar from glucuronidated compounds as a source of carbon,resulting in activation of drugs from its non-toxic form to toxic chemicals [1].

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