论文部分内容阅读
The nucleolus,also known as"ribosomal factory",is the subnuclear site of ribosome biogenesis.
Nucleolar-Targeting Platinum-based Agent Expresses Increased Toxicity and Overcomes Platinum Drug Re
【摘 要】
：
The nucleolus,also known as"ribosomal factory",is the subnuclear site of ribosome biogenesis.
【机 构】
：
Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Cl
【出 处】
：
中国化学会第十届全国化学生物学学术会议
【发表日期】
：
2017年10期
其他文献
利用无毒的三苯基铋为催化剂催化生物基来源的两种单体十三烷二酸环乙撑酯(EB)和δ-戊内酯(δ-VL)开环聚合，得到了一系列EB 含量由0-100％的不同比例的共聚物.150℃条件下在相对较短的时间内(36h)得到了高分子量的聚合物.
Due to the elevated anaerobic metabolism of cancerous cells,their demand for glucose is much higher than that of normal cells.
Constructing novel metal-arene complexes containing bioactive natural-product derived ligands is an important approach to further drug design.Herein,we reported two novel ruthenium(Ⅱ)-arene complexes(
Design and Synthesis of Pyruvate Dehydrogenase Complex E1 Inhibitors with Cyanobacteria Inhibitory A
The pyruvate dehydrogenase complex(PDHc)in microorganism plays a vital role in cellular metabolism and catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A(
An interesting class of cyclic boron-containing compounds,benzoxaboroles,were first synthesized in 19571 while its medicinal usage had remained unexplored for fifty years until tavaborole(Kerydin)(Fig
会议
Design,synthesis and biological evaluation of new 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives
To find novel pyruvate dehydrogenase complex E1 component(PHDc-E1)inhibitors as fungicides,two series of 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives were designed,synthesized,and evaluated for
The worldwide outbreak of severe acute respiratory syndrome(SARS)in 2003 had caused a high rate of mortality.Main protease(Mpro)of SARS-associated coronavirus(SARS-CoV)is an important target to discov
Aberrant epigenetic alterations of tumor suppressor genes have been recognized as a driving force in cancer.Histone deacetylases(HDACs),for example,are promising targets for cancer due to their crucia
First identification of isatin-β-thiosemicarbazones as novel inhibitors of New Delhi metallo-β-lacta
New Delhi metallo-β-lactmase-1(NDM-1)catalyzes the hydrolysis of β-lactam antibiotics and cleaves the β-lactam ring of the molecule,conferring resistance against these medicines to bacteria.
Monofunctional Platinum Anticancer Agents Containing RNA Polymerase I Inhibitors Overcome Platinum D
Accelerated proliferation of cancer cells is linked to increased transcription of rDNA by RNA polymerase I(Pol I)to produce elevated levels of rRNA for ribosomal biogenesis.