Natural nacre supplies a number of properties that can be used in designing high-performance bioinspired materials.Likewise,due to the extraordinary properties of graphene,a series of bioinspired graphene-based materials have recently been demonstrated.Compared to other approaches for constructing graphene based materials,bioinspired concepts result in high-loading graphene,and the resultant high-performance graphene-based artificial nacres demonstrate isotropic mechanical and electrical properties.Here we show how to construct integrated graphene-based artificial nacre through the synergistic relationship between interface interactions and building blocks.These integrated graphene-based artificial nacres show promising applications in many fields,such as aerospace,flexible supercapacitor electrodes,artificial muscle,and tissue engineering.