【摘 要】
：
Background Inflammatory and oxidative damage play a pivotal role in cerebral ischemic pathogenesis and may represent a therapeutic target.Octreotide (OCT) has been proved to elicit a variety of biolog
【机 构】
：
Department of Neurology,Second Hospital of Hebei Medical University
论文部分内容阅读
Background Inflammatory and oxidative damage play a pivotal role in cerebral ischemic pathogenesis and may represent a therapeutic target.Octreotide (OCT) has been proved to elicit a variety of biological effects through its anti-inflammatory and anti-oxidant properties in the treatment of severe acute pancreatitis and ischemia-reperfusion injury in retina and intestine.However,little is known regarding the effect of OCT in ischemic stroke.Here,we designed this study to investigate the protective effect of OCT in ischemic stroke and explore the potential underlying mechanisms.
其他文献
Gamma-secretase inhibitor,N-[N-(3,5-difluor-ophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT) suppresses the activation of Notch 1 signaling,which is recognized as the cell fate signaling an
There is cumulative evidence that the serine-threonine kinase Akt and its downstream nuclear transcription factor CREB are involved in neuronal survival and protection.The Akt activates and phosphoryl
目的 通过观察缺血性卒中后内源性抑郁大鼠额叶及杏仁核的脑源性生长因子(BDNF)、受体酪氨酸激酶B (TrkB)及磷酸化酪氨酸激酶B(pTrkB)的表达,探讨缺血性卒中后内源性抑郁的发病机制.方法 将SD雌性大鼠随机分为对照组、模型组和雌激素组.对照组去卵巢,不予任何刺激;模型组去卵巢1周后,予以大脑中动脉栓塞术(Middle cerebral artery occlusion,MCAO)后饲养2
目的 探讨α-硫辛酸(LA)对组织氧化所致小鼠脑损伤的作用及其保护机制探讨.方法 40只Wistar小鼠,随机分为对照组、模型组、研究组.对照组常规饲养,模型组和研究组均进行股动脉放血并双侧颈总动脉夹闭,其中模型组制模后给予生理盐水,研究组给予LA 10 μmol/kg、30 μmol/kg.测定其谷胱甘肽(GSH)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水
背景与目的 脑梗死是常见的脑血管病,随着人口老龄化、生活方式改变及气候异常变化等原因,其发病率呈逐年上升趋势.研究脑梗死发病的规律和影响因素,对预防脑梗死的发生和提高生活质量具有重要意义.许多研究表明脑梗死的发病存在明显季节规律,然而对脑梗死发病的季节规律研究结果不一,有的甚至出现相反的结果.本文对我院近年收治的初发急性脑梗死患者发病情况的时间变化规律进行分析,探讨脑梗死发病与时间变化的关系,以采
Multipotent human adipose-derived stromal/stem cells (hADSCs) hold a great promise for cell-based therapy for many devastating human diseases such as spinal cord injury,stroke et al.If exogenous hADSC
目的 细胞凋亡是缺血性脑卒中的主要病理过程,因此干预细胞凋亡对改善缺血性脑卒中的预后有一定意义.目前与凋亡相关的基因分为抗凋亡基因和促凋亡基因,其中Fas、FasL是最重要的促凋亡基因,参与了脑缺血损伤后的发生、发展.本研究观察丁苯酞对大鼠脑缺血再灌注损伤后Fas、FasL表达的影响,从分子水平探讨丁苯酞对缺血性脑损伤的保护作用机制.方法 实验大鼠随机分为3组:假手术组(Sham组)、脑缺血再灌注
Background Matrine has been proven to protect ischemic injury in brain and sophoridine (SOP)is an isomeride of matrine.It is unknown whether SOP has this protective effect on ischemic injury in brain.
Background It has been proved that pre-treatment with leonurine could protect brain tissue against ischemic injury by exerting antioxidant effects and regulating mitochondrial function.Whether this pr
Luteolin recently has been proved to elicit a vanity of biological effects through its antioxidant and anti-apoptosis properties.Oxidative and apoptosis damage play an important role in cerebral ische