【摘 要】
：
Objective Chronic unpredictable stress was commonly used to evoke depression-like behavior in rat.The present study was undertaken to investigate the effect of chronic unpredictable stress on conditio
【机 构】
：
Department of Humanity and Manage, Cell Electrophysiology Lab
【出 处】
：
中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
Objective Chronic unpredictable stress was commonly used to evoke depression-like behavior in rat.The present study was undertaken to investigate the effect of chronic unpredictable stress on conditioning fear behavior and somatosensory evoked potential (SEP) of rats.The correlation of the conditioning fear behavior and SEP was also evaluated.Methods Twenty-seven male SD rats (weight 190-200 g) were random divided into control group and model group.Rats in model group were subjected to chronic unpredictable stress.Conditioning fear behavior of rats was observed with Freeze monitor system and the latency of somatosensory evoked potential was evaluated with Powerlab system.Results Compared with control group, rats in model group had decreased freezing behavior responded to the sound stimulation during fear memory stage (56.64% ± 13.78%, n =13, vs 69.72% ± 18.10%, n =14, P < 0.05, mean±SD).The latency of SEP decreased in the rats treated with chronic unpredictable stress (70.54 ± 10.13 ms, n =14 vs 78.46 ± 7.80 ms, n =14, P < 0.05), which had the significant difference between the two group rats.The correlation coefficient of the conditioning fear behavior and SEP was positive (r =0.507, P < 0.05).Conclusion Chronic unpredictable stress inhibited conditioning fear behavior of rats, decreased latency of SEP, which suggests chronic unpredictable stress stimulations active the neurotransmitter network system involved with both conditioning fear behavior and SEP.
其他文献
Objective Hydrogen sulfide (H2S) plays a critical role in regulation of brain function.However, its impact on neurodegenerative disease is still unknown.The present study was undertaken to investigate
Objective Irwin test is one of the most commonly used assays for pre-clinical neuro-toxicological screenings.As a descriptive assay, there are many disadvantages in its original data analysis and pres
Objective Previous studies showed that the superior temporal gyrus and sulcus (STG/STS) plays an important role in auditory speech processing.In this study, we investigated whether the activation of t
Soluble amyloid-β protein (Aβ) plays a central pathogenic role in Alzheimers disease (AD).Memantine, a low-affinity N-methyl-D-aspartate receptor (NMDAR) antagonist, exerts neural protective effects i
Objective Working memory is divided into separable subsystems, spatial working memory and verbal working memory involving manipulation and retention ofvisuospatial and verbal information respectively.
Objective Fusiform face area (FFA) is highly specialized for faces and independent of task modulation.This study was to test the stability of FFA response to face information across 4 fMRI scans spann
Objective The hippocampal parallel excitatory pathways referred to as the trisynaptic pathway (entorhinal cortex → dentate gyrus → CA3 → CA1) and the monosynaptic pathways (entorhinal cortex → CA1, en
Objective Recent studies on meditation revealed that short-term or long-term meditation training could improve attention.In these studies, participants who attended meditation training could perform b
Objective Contrast sensitivity to visual stimulus shows an evident dependency on stimulus spatial frequency in many species of vertebrates.The neural basis remains unclear.Here, we investigated the ro
Objective Neurons containing gamma-aminobutyric acid (GABA) play an important role in the regulation from wakefulness to sleep.Recent evidences have demonstrated that the interaction between GABAergic