Multidrug resistance (MDR) is one of the major reasons for the failure of chemotherapy.In this study, a series of pluronic unimers was conjugated to polyamidoamine (PAMAM) dendrimers.Do xo rub if in (DOX) was loaded to these conjugates, which aimed to reverse drug resistance in MCF-7/ADR cells by targeted and effective delivery of the pluronic unimers into cells.Pluronic F127 (PF127) and F68 (PF68) with different ratios were conjugated to PAMAM dendrimer to investigate the influence of type and quantity of pluronic.Drug release analysis showed that the DOX-loaded conjugates exhibited sustained and pH-sensitive release behavior.