【摘 要】
：
Hydroxysafflor yellow A (HSYA), the main active pharmaceutical ingredient of the safflower plant (Carthamus tinctorius L.), is a hydrophilic drug with low o
【机 构】
：
Department of Pharmaceutics,Beijing Institute of Pharmacology and Toxicology,Haidian district,Beijin
【出 处】
：
2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
Hydroxysafflor yellow A (HSYA), the main active pharmaceutical ingredient of the safflower plant (Carthamus tinctorius L.), is a hydrophilic drug with low oral bioavailability (BA).The objective of the present study was to improve the oral BA of HSYA by formulation design.The main reason for the low oral BA of HSYA is its low liposolubility and high water-solubility, which can hinder its penetration across the epithelial monolayer.Some pharmaceutical excipients have been shown to enhance the permeability of BCS Ⅲ drugs, such as sodium caprate (SC), sodium deoxycholate, β-cyclodextrin (β-CD) and Poloxamer 188 (P188).Therefore, the above five excipients were selected to investigate their ability to enhance the oral BA of HSYA through animal models.
其他文献
Nowadays, lots of investigators draw attention to multidrug resistance(MDR) in cancer.The MDR is mostly due to the overexpressing of P-glycoprotein(P-gp).In
Peptide dendritic polymer based nanoparticles have presented significant potential to be a candidate for drug/gene delivery system owing to the features of
Objective: To enhance the effective diagnosis of tumor by magnetic resonance imaging (MRI), aptamer-targeted liposomes combined with gadolinium (Gd) were de
Polyhydroxyalkanoate (PHA) is a class of polyesters and synthesized in various microorganisms.Due to biodegradable and good biocompatibility, PHA have been
The combination of doxorubicin (DOX) with sorafenib (SOR) has been proved to be an effective strategy to enhance anti-hepatocellular carcinoma (HCC) efficie
笔者以西班牙作家霍尔迪·塞拉·依·法布拉的儿童文学作品《无字书图书馆》为例,谈谈课外阅读分享课的教学设计:rn一、阅读回访,基于学生的真实阅读rn《无字书图书馆》阅读
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
Pingyangmycin hydrochloride (PYM) is an effective sclerosing agent to treat vascularmalformations(VM), but can easily diffuse from the injection site, which