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10-Hydroxycamptothecin (HCPT) and doxorubicin (DOX) are inhibitors of topoisomerase Ⅰ and topoisomerase Ⅱ respectively.Therefore, combination therapy using HCPT and DOX is possible and significant to clinic application.Unfortunately, different pH of their commercial injections prevents the simultaneously i.v.injection with simply mixture in application due to the possible precipitation.