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d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS), a water-soluble derivative of natural vitamin E, has been intensively used in drug delivery systems.TPGS (CoQ10-NE-TPGS) and lecithin-based (CoQ10-NE-LC) coenzyme Q10-1oaded nanoemulsions were prepared by hot high-pressure homogenization (HPH) and tested for their ability to target heart tissue.