Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal lung disease of unknown etiology, characterized by myofibroblast accumulation and subsequent extracellular matrix (ECM) deposition.Evidence suggests that the disease process is initiated through alveolar epithelial cell microinjuries and apoptosis, which results in the expansion of myofibroblasts population in the IPF lungs.