IDO在BMSCs对初始T细胞向Th17/Treg细胞分化中的作用及机制

来源 :全国第二十三届烧伤专业委员会学术会议 | 被引量 : 0次 | 上传用户：winxb

【摘要】

：

目的初步验证吲哚胺2,3-双加氧酶(IDO)在BMSCs对初始CD4+T细胞向Th 17/Treg细胞分化的影响及其可能机制.方法分离培养Balb/c小鼠来源的BMSCs,以Balb/c小鼠脾脏来源的CD4+T细胞为反应细胞,以丝裂霉素预处理过的C57BL/6小鼠脾脏细胞作为刺激细胞.实验分为3组：对照组,刺激细胞+反应细胞；BMSCs组,刺激细胞+反应细胞+BMSCs；IDO拮抗组,刺激细胞

【作者】

：

王耘川王许杰高建新刘洋郑朝官浩朱雄翔韩军涛胡大海

【机构】

：

第四军医大学西京医院烧伤与皮肤外科·全军烧伤中心西安710032

【出处】

：

全国第二十三届烧伤专业委员会学术会议

【发表日期】

：

2015年4期

【关键词】

：

间充质干细胞免疫耐受调节6性T细胞 Th17 吲哚胺2 3-双加氧酶

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IDO在BMSCs对初始T细胞向Th17/Treg细胞分化中的作用及机制

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