【摘 要】
：
背景：缺血性中风导致少突胶质细胞的死亡，从而引发轴突脱髓鞘的白质病变。由于少突胶质祖细胞(OPC)不能有效的向脱髓鞘部位迁移或分化成少突胶质细胞，所以很难实现脱髓鞘部位的再髓鞘化。尽管有证据表明趋化因子SDF-1能够调节多种干细胞的迁移、增殖和分化，但没有试验研究SDF-1在缺血造成白质损伤后在再髓鞘化过程中的作用和机制。
【机 构】
：
上海交通大学生物医学工程学院和Med-X研究院 上海交通大学医学院附属瑞金医院神经内科
【出 处】
：
长三角地区神经科学论坛暨浙江省神经科学学会2014年年会
论文部分内容阅读
背景：缺血性中风导致少突胶质细胞的死亡，从而引发轴突脱髓鞘的白质病变。由于少突胶质祖细胞(OPC)不能有效的向脱髓鞘部位迁移或分化成少突胶质细胞，所以很难实现脱髓鞘部位的再髓鞘化。尽管有证据表明趋化因子SDF-1能够调节多种干细胞的迁移、增殖和分化，但没有试验研究SDF-1在缺血造成白质损伤后在再髓鞘化过程中的作用和机制。
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