FAM129A overexpression promotes ccRCC clinical progression by enhancing patient's TNM stage and

来源 :中国生物化学与分子生物学会2019年全国学术会议 | 被引量 : 0次 | 上传用户:l447863596
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Clear cell renal cell carcinoma(ccRCC)is the most aggressive RCC subtype.It is characterized with high rates of local invasion and metastasis,resistances to chemotherapy and radiotherapy.
其他文献
Sirtuins(SIRTs)are a class of lysine deacylases that regulate cellular metabolism and energy homeostasis.Although sirtuins have been proposed to function in nutrient sensing and signaling,the underlyi
The Streptococcus pneumoniae fatty acid synthesis pathway is globally controlled at the transcriptional level by repressor FabT and its co-repressor acyl cattier protein(acyl-ACP),the intermediate of
The Caudovirales,known as tailed bacteriophages,comprises the vast majority(>95%)of bacteriophages.They all have in common a proteinaceous head,which encloses a single linear double-stranded DNA,and a
The novel post-translational modification,lysine 2-hydroxyisobutyrylation(Khib),has recently been thought to be an evolutionarily conserved histone mark.
Hepatocellular carcinoma(HCC)is the third leading cause of most common cancer-related deaths due to its higher metastasis,recurrence and chemoresistance.
索拉非尼作为FDA批准的首个肝癌分子靶向药物,其有效性和安全性得到广泛认可,但是也有相当一部分接受索拉非尼治疗的患者,不但没有确切的疗效,反而增加由此带来的副作用和沉重的经济负担。如何抑制肝癌细胞索拉非尼耐药的发生,提高其治疗效果,逐渐成为近年来人们关注的热点。
Cyanobacteria are prokaryotes,also known as “blue-green algae”,which can execute photosynthesis and thus play an important role in the early formation of the Earth′s atmosphere.
The aim of the study was to examine the inhibitory effects and the related mechanisms of 17β-estradiol(E2)on triglyceride synthesis and insulin resistance in skeletal muscle tissues and cells.
BCR-ABL kinase activation triggers the downstream signaling molecules including phosphoinositide 3-kinase(PI3K)/Akt,FAK/Src,STAT5 and c-MYC.
糖链是继核酸、多肽蛋白质后的第三条重要的生命分子链,而细胞内至少超过50%的蛋白质都是有糖链修饰的。糖链参与了包括细胞识别、细胞分化、发育、信号转导、免疫应答等各种重要生命活动。在肿瘤等人类现代重要疾病发生、发展中均伴随着蛋白质糖基化异常的发生,而糖基化异常调控肿瘤细胞恶性行为,并成为临床诊断和治疗的靶点。