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Multidrug resistance(MDR)is the major obstacle of the success in cancerchemotherapy.The overexpression of ATP-binding cassette(ABC)transporters,particularly ABCB1,ABCC1 and ABCG2,play a significant role in mediating MDR by pumpinganticancer drugs out from cancer cells.Abemaciclib(LY2835219)is an orally bioavailable CDK4/6 inhibitor under phase Ⅲclinical trials.