【摘 要】
：
Indole frameworks, especially chiral ones, are widely distributed in a large number of bioactive natural products and pharmaceuticals.1 Owing to the importance of these bioactive indole derivatives, i
【机 构】
：
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemsitry, Nankai
论文部分内容阅读
Indole frameworks, especially chiral ones, are widely distributed in a large number of bioactive natural products and pharmaceuticals.1 Owing to the importance of these bioactive indole derivatives, it is not surprising that enormous efforts have been devoted to the development of efficient syntheses of enantioenriched indole derivatives.On the other hand, the interest in the thiopyran heterocycles has been significantly surged since a wide range of biological activities associated with the scaffold have been identified.2 Among the thiopyrans, the thiopyran fused indole derivatives are found to possess some interesting bioactivities.
其他文献
Since Kagan showed the importance of conformational rigidity in the design of ligand or catalyst structure,1 the concept of conformations and enantioselectivity of chiral ligands and catalysts has bee
The Diels-Alder reaction, [4+2] cycloadditions between electronically matched dienes and dienophiles, is one of synthetic organic chemists text-book reactions.[1] Though Bronsted acids or Lewis acids
不对称碳-碳键形成反应是最基础的反应之一.过渡金属催化的有机金属试剂对α,β-不饱和烯酮的1,4-共轭加成和钯催化的烯丙基烷化反应作为重要的碳-碳键形成反应,被广泛用于许多天然产物的合成.先前,我们以L-(+)-酒石酸和联萘酚衍生物为原料,合成了一系列新型的手性双齿亚磷酸酯配体(如图式一),并将其应用于1,4-共轭加成反应中.研究结果表明,具有(R)-或者(S)-的联萘酚,以及含有三甲基硅取代基联
Over the past few years, great efforts have been devoted to the synthesis of functionalized molecules with a CF3-containing stereocenter because of their superior biological properties.[1] In particul
The Hetero-Diels-Alder (HDA) reaction provides a powerful tool to construct aza, oza-heterocycles, in which Danishefskys diene was demonstrated to be the most efficient diene.1 Based on our groups eff
As we know, the carboxylic acid proton in amino acid plays a critical role in enhancing the reactivity and stereoselectivity of catalyst.[1] Accordingly, increasing the acidity of amino acid based cat
Ferrocenes, as well as other planar chiral molecules have recently attracted significant attention in the field of both synthetic chemistry, material science and bioorganometallic chemistry.Ferrocene
The indole framework represents one of the most important structural units frequently found in natural products, pharmaceuticals, and other synthetics.1 Among the numerous indole derivatives, polycycl
Quinoxalines are an important class of nitrogen-containing heterocyclesthat possess a broad spectrum of physiological and biological activities.1 Although a number of methods are available for the syn
A novel chiral biphosphine ligands, 6,6-bis(diphenylphosphino)-5,5-biquinoline (BIQAP) was synthesized by two step reactions used optical pure BIQOL as starting material and the molecular structure of