双齿亚磷酸酯配体在碳-碳键形成反应中的应用

来源 :手性中国2014学术研讨会 | 被引量 : 0次 | 上传用户：tulip126

【摘要】

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【作者】

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邢爱萍逄增波王来来

【机构】

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中科院兰州化学物理研究所,羰基合成与选择氧化国家重点实验室,甘肃,兰州,730030;中国科学院研究生院,北京,100039

【出处】

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手性中国2014学术研讨会

【发表日期】

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2014年3期

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不对称碳-碳键形成反应是最基础的反应之一.过渡金属催化的有机金属试剂对α,β-不饱和烯酮的1,4-共轭加成和钯催化的烯丙基烷化反应作为重要的碳-碳键形成反应,被广泛用于许多天然产物的合成.先前,我们以L-(+)-酒石酸和联萘酚衍生物为原料,合成了一系列新型的手性双齿亚磷酸酯配体(如图式一),并将其应用于1,4-共轭加成反应中.研究结果表明,具有(R)-或者(S)-的联萘酚,以及含有三甲基硅取代基联萘酚骨架的配体,在该反应中获得较高的活性和ee值;当底物是环戊烯酮或环己烯酮时,在该反应中都获得大于90％的对映选择性;产物的构型主要是由联萘酚基团的构型决定的.

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双齿亚磷酸酯配体在碳-碳键形成反应中的应用

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