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5. The proteasome inhibitor MG132 enhances LDL uptake in hepatocytes through regulating LDLR and PCSK9

The proteasome inhibitor MG132 enhances LDL uptake in hepatocytes through regulating LDLR and PCSK9

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：doni123

【摘 要】

：

Aim: The low-density lipoprotein receptor (LDLR), a determinant regulator in cholesterol homeostasis, is tightly regulated in liver cells.Previous studies demonstrated that the degradation of LDLR is

【作 者】

：

Hong YAN Yan-ling MA Xin-bo WANG Yu-zhou GUI Fei GAO Yi-ping WANG 

【机 构】

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State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Scie

【出 处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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Low-density lipoprotein receptor proprotein convertase subtilisin/kexin type 9 p 

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Aim: The low-density lipoprotein receptor (LDLR), a determinant regulator in cholesterol homeostasis, is tightly regulated in liver cells.Previous studies demonstrated that the degradation of LDLR is lysosome dependent, whereas the evidence for the involvement of proteasome in LDLR regulation is relatively rare.

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