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Background and Objective Caspase-8 (CASP8) is essential for activation of the extrinsic apoptosis pathway.A polymorphic variant-652 6N ins/del (rs3834129) in promoter of CASP8 gene has been reported to decrease caspase-8 expression and its activity in T lymphocytes.The present study aimed to investigate the association between the polymorphism and risk ofT-cell lymphomas (TCLs) in Chinese.