【摘 要】
：
目的 运用静息态fMRI技术研究IBS患者脑内相关功能兴奋区和正常志愿者之间低频涨落振幅(ALFF)值的差异.方法 纳入符合2006年罗马Ⅲ标准的腹泻型肠易激综合征(IBS-D)患者31例,同时纳入在性别、年龄、受教育程度、利手与患者相匹配的非IBS健康志愿者20例.所有受试者给予Siemens 3.0T超导磁共振静息态成像,解剖图像用三维快速扰相梯度翻转恢复(3D-FSPGR)序列采集,fMRI
【机 构】
：
浙江省立同德医院 杭州 310012 临安市人民医院 杭州 311300
【出 处】
：
中国中西医结合学会医学影像专业委员会第十五次全国学术大会暨上海市中西医结合学会医学影像专业委员会2017年学术年会
论文部分内容阅读
目的 运用静息态fMRI技术研究IBS患者脑内相关功能兴奋区和正常志愿者之间低频涨落振幅(ALFF)值的差异.方法 纳入符合2006年罗马Ⅲ标准的腹泻型肠易激综合征(IBS-D)患者31例,同时纳入在性别、年龄、受教育程度、利手与患者相匹配的非IBS健康志愿者20例.所有受试者给予Siemens 3.0T超导磁共振静息态成像,解剖图像用三维快速扰相梯度翻转恢复(3D-FSPGR)序列采集,fMRI扫描序列采用T2-平面回波成像一梯度回波(EPI-GRE)序列.扫描完成后运用“DPARSF”软件对数据进行预处理,采用低频涨落振幅(Amplitude of low frequency fluctuation,ALFF)作为评价指标,比较IBS组和健康对照组之间静息态下ALFF值的差异.结果 与健康对照组相比,IBS组静息状态表现出ALFF增强的脑区有双侧丘脑、右侧海马、左侧海马旁回、双侧顶下回、右侧小脑前叶、小脑蚓部、双侧枕下回、左枕中回；ALFF值减弱的脑区有双侧额叶、左前扣带回、右侧岛叶(双样本t检验,P＜0.001,校正后).结论静息状态下,IBS患者与健康对照组ALFF值存在差异,而且ALFF值降低的脑区与脑内默认网络区域关系密切,这可能有助于IBS的中枢发病机制的研究.
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