ATP1A3而非ATP1A2基因多态性与遗传性全面性癫痫相关

来源 :中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议 | 被引量 : 0次 | 上传用户：jplayer2

【摘要】

：

目的:ATP1A2和ATP1A3是编码钠-钾-ATP酶的一组基因,钠-钾-ATP酶在神经细胞电生理方面起着重要作用,本实验研究ATP1A2和ATP1A3基因多态性是否对中国遗传性全面性癫痫患者的易感性与抗癫痫药物疗效有影响.方法:在484个中国遗传性全面性癫痫患者(其中药物反应患者280个,药物耐受患者204个)和284各健康对照中测定ATP1A2基因6个标签SNP和ATP1A3基因2个标签SNP

【作者】

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屈健张颖茆晨雪王志斌刘昭前

【机构】

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中南大学湘雅医院临床药理研究所,长沙410008,中国中南大学临床药理研究所,遗传药理学湖南省重

【出处】

：

中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议暨第六届国际药物警戒与药物安全学术会议

【发表日期】

：

2014年3期

【关键词】

：

遗传性全面性癫痫 ATP1A2 ATP1A3 多态性抗癫痫药物

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ATP1A3而非ATP1A2基因多态性与遗传性全面性癫痫相关

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