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PTD-SOD is a reombinant antioxidant enzyme we prepared by fusing a protein transduction domain with hCu,Zn-SOD, with capability to traverse into cell to remove.haddition to its prominent intracellular antioxidant activity, we also notice PTD-SODs whitening effect on skin.To understand its mechanism, the PTD-SODs tyrosinase activity was investigated in vitro using dopa, and the skin whitening effect was studied using mice model.