基于鲨鱼免疫系统的PD-1抗原单域抗体的初步研究

来源 :中国生物化学与分子生物学会2019年全国学术会议 | 被引量 : 0次 | 上传用户：cry87ac

【摘要】

：

鲨鱼单域抗体(single-domain antibodies,sdAbs)是目前已知最小且能与抗原发生特异性结合活性的抗体分子,其分子量低至12kDa左右。因其具有分子量小、溶解能力强等特点,可以穿过血脑屏障,更有效的与抗原结合。鲨鱼单域抗体的FR1与CDR3和CDR3与FR3之间还存在两对非典型的二硫键,因此其作为药物能更加稳定地存在于机体内,更好发挥作用。

【作者】

：

吴溢鑫崔轩胡智奕钟波田琦肖楚琼吕正兵

【机构】

：

浙江理工大学生命科学与医药学院,杭州,310018

【出处】

：

中国生物化学与分子生物学会2019年全国学术会议

【发表日期】

：

2019年10期

【关键词】

：

单域抗体条纹斑竹鲨 PD-1抗体免疫疗法

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基于鲨鱼免疫系统的PD-1抗原单域抗体的初步研究

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