RasGRP3抑制巨噬细胞Toll样受体介导的炎症反应

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：fairylky

【摘要】

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研究背景:Toll样受体(TLR)的活化是一把双刃剑,过度的活化则导致损伤性的炎症反应和继发的自身免疫病,因此TLR的信号传导必须受到严格的调控.小G蛋白(如Ras、Rap)是一种分子量较小的可以结合GTP/GDP并水解GTP的重要蛋白质家族,其与TLR信号传导的关系目前研究极少,尤其是小G蛋白分子的调控分子与TLR以及天然免疫的关系目前尚未见相关报导.目的:探讨Ras鸟苷酸释放蛋白(Ras gu

【作者】

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陈涛涌唐松青曹雪涛王建莉

【机构】

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医学免疫学国家重点实验室暨第二军医大学免疫学研究所浙江大学免疫学研究所

【出处】

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中国免疫学会第九届全国免疫学学术大会

【发表日期】

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2014年8期

【关键词】

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TLR RasGRP3 Rap1 炎症反应巨噬细胞

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RasGRP3抑制巨噬细胞Toll样受体介导的炎症反应

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