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PURPOSEToevaluatethedetectionabilityoffocalliverlesions(FLLs)usinglowdosecontrast-enhancedabdominalCTwith differentreconstructiontechniquescomparedtomagneticresonanceimaging(MRI)asreference. METHOD AND MATERIALS41patientswithsuspectedliverdiseaseunderwentlowdosecontrast-enhancedabdominalCTand abdominalMRIwithanintervalnomorethan5days.ForCTscan,atotalof4acquisitionsincludingplainscan,hepaticarterial phase,portalveinphase,anddelayedphasewereobtainedwithascanrangefromthedomeofthediaphragmtothepubic symphysisineachpatient.Imagedatawasreconstructedwithfilteredbackprojection(FBP),hybriditerativereconstruction(HIR) anditerativemodelreconstruction(IMR)techniques.Thenumber,site,andsize(maximumdiameter)ofFLLswererecorded.The sensitivity,specificity,positivepredictivevalue(PPV),negativepredictivevalue(NPV),andaccuracyoflowdoseCTwithdifferent reconstructiontechniqueswereevaluatedfordifferentsizeofFLLs. RESULTSThemeaneffectiveradiationdoseofCTexaminationswas9.9mSv±1.7.Atotalof162FFLsweredetectedbyMRI(59/48/25/30ofmaximumdiameter<=0.5cm/0.5cm-1.0cm/1.0cm-2.0cm/>=2.0cm,respectively).Thesensitivity,specificity,PPV, NPV,andaccuracyofdifferentreconstructiontechniqueswereshowedinTable1(uploadasafigure).BetteraccuracyofCT-IMR wasobtainedfordetectionofFLLswithmaximumdiameternomorethan1.0cm,whencomparedtoHIRandFBP. CONCLUSION100%accuracyoflowdosecontrast-enhancedabdominalCTwasachievedascomparedtoMRIinFFLdetection withlesiondiameterlargerthan1.0cm.ForsmallFLLs(<=1.0cm),CT-IMRachievedbetteraccuracythanHIRandFBP. CLINICALRELEVANCE/APPLICATIONBetterdiagnosticperformanceoflowdosecontrast-enhancedabdominalCTinsmallfocal liverlesionevaluationmayachievedbytheuseofIMRtechnique.