【摘 要】
：
The lack of efficient antigens and activators delivery systems[1],as well as the restricted migration of dendritic cells(DCs)to secondary lymph organs,dramatically limits DCs-based adoptive immunother
【机 构】
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Institute of Transfusion Medicine,Academy of Military Medical Sciences,Beijing,100850,China
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
The lack of efficient antigens and activators delivery systems[1],as well as the restricted migration of dendritic cells(DCs)to secondary lymph organs,dramatically limits DCs-based adoptive immunotherapy[2].We selected two spherical gold nanoparticles(AuNPs)-based vehicles of optimal size for activator and antigen delivery.Their combination(termed as NanoAu-Cocktail)was associated with dual-tareting of CpG oligonucleotides(CpG-ODNs)and OVA peptide(OVAp)to DCs subcellular compartments,inducing enhanced antigen cross-presenting,up-regulated expression of costimulatory molecules(CD40,CD80 and CD86)and elevated T helper1(Th1)cytokine secretion(e.g.,IL-12p70,TNF-α).
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