Purpose: To investigate the function and mechanism of IL-22 during oral mucosal wound healing Methods: Expression level of IL-22 and STAT3 were investigated via a mice tongue wound model in vivo,and in vitro study was checked with Real-time PCR,Western blotting and proliferation assays in keratinocytes and fibroblast.Results: The results showed that IL-22 and p-stat3 were associated with oral mucosa wound healing,and STAT3 was activated when the keratinocytes and the tongue tissue were stimulated by IL-22.But fibroblasts showed negative result.Conclusion: In summary,our study suggests that IL-22 can promote the oral mucosa wound healing via STA3 in keratinocytes.