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Covalent attachment of poly(ethylene glycol)(PEG) molecules to drugs,proteins,nanoparticles and liposomes is a proven technology for improving their bioavailability,safety,and efficacy.Qualitative and quantitative analysis of PEG-derivatized molecules is important for both drug development and clinical applications.We previously developed the anti-PEG antibodies(AGP3 and E11...) that specifically bind to the different repeating(O-CH2-CH2)n subunits of PEG.