【摘 要】
：
Objective: Both estrogen receptors, ERalpha (ERα) and ER beta (ERβ), are expressed in 50-70% of breast cancer tissue.The role of ERα as a prognostic mark
【机 构】
：
Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health and Family Medici
【出 处】
：
首都医科大学公共卫生学院第三届研究生学术论坛
论文部分内容阅读
Objective: Both estrogen receptors, ERalpha (ERα) and ER beta (ERβ), are expressed in 50-70% of breast cancer tissue.The role of ERα as a prognostic marker in breast cancer has been well established as its expression negative correlated with tumor size and lymph node metastasis.ERβ is also a favorable prognostic predictor for breast cancer although it was less documented than ERα.Materials and methods: To explore whether ERs independently or their coexpression influences clinical outcomes in breast cancer, the correlation between the ERs with the clinicopathological features was analyzed in 84 patients.Results: ERα expression negatively correlated with tumor stage (r=-0.246, p=0.028) and trended to be negatively correlated with lymph node status(r=-0.156,p=0.168) and tumor size(r=-0.246, p=0.099).Also, ERβ was negatively correlated with nodal status (r=-0.243, p=0.028).Finally, the coexpression of ERα and ERβ negatively correlated with nodal status (p=0.043, OR=0.194, 95% CI=0.040-0.953).Conclusions:Coexpression of ERs might serve as a good prognosis in breast cancer patients.
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