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5. Group-combined P-values with applications to genetic association studies

Group-combined P-values with applications to genetic association studies

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：owennb1

【摘 要】

：

Motivation: In large-scale genetic association studies with tens of hundreds of single nucleotide polymorphisms(SNPs)genotyped,the traditional statistical framework of logistic regression using maximu

【作 者】

：

Xiaonan Hu Wei Zhang Sanguo Zhang Shuangge Ma Qizhai 

【机 构】

：

University of Chinese Academy of Sciences,China A

【出 处】

：

上海交通大学

【发表日期】

：

2016年4期

【关键词】

：

Group-combined p-values Genetic association Power 

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　　Motivation: In large-scale genetic association studies with tens of hundreds of single nucleotide polymorphisms(SNPs)genotyped,the traditional statistical framework of logistic regression using maximumlikelihood estimator(MLE)to infer the odds ratios of SNPs may notwork appropriately.

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